ACE2 inhibitor MB-32

Chemical Structure : ACE2 inhibitor MB-32

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货号: PC-26986Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MB‑32 is a specific, allosteric inhibitor of angiotensin‑converting enzyme 2 (ACE2) with KD of 7.078 and 3.997 uM in SPR and BLI assays, selectively disrupts binding of SARS‑CoV‑2 spike receptor‑binding domain to ACE2, MB-32 is a potent and specific broad-spectrum entry inhibitor of pan-sarbecoviruses.
MB‑32 potently inhibits entry of SARS‑CoV‑2 variants, SARS‑CoV‑1 and diverse bat/pangolin sarbecoviruses in ACE2‑expressing cells, while sparing vesicular stomatitis virus and authentic MERS‑CoV, indicating non‑virucidal, ACE2‑focused activity.
MB‑32 engages a non‑catalytic surface pocket on the ACE2 N‑terminal helix to allosterically disrupt spike attachment.
MB-32 exhibited broad-spectrum activity against SARS-CoV-2 VOCs, with a mean IC50 of 196 nM (range 13.4-532 nM).
MB-32 does not inhibit ACE2 enzymatic activity, does notinhibit TMPRSS2 or Cathepsin L.
MB-32 (60 µg/mouse, 2.33 mg/kg body weight, intranasal (i.n.) administration) demonstrates potent antiviral efficacy in K18-hACE2 transgenic mice and prevents natural transmission against SARS-CoV-2 VOCs.
MB-32 rescues hACE2 transgenic Mice from lethal SARS-CoV-2 infection, with no observable adverse effects.

物理化学性质&存储条件

分子量	534.64
分子式	C26H30N8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethyl)-3-(6-(4-methylpiperazin-1-yl)-2-(p-tolyl)benzo[d]thiazol-5-yl)urea

参考文献

1. Liu L, et al. Nat Commun. 2026 Jun 6. doi: 10.1038/s41467-026-73944-x.