ACC2 inhibitor 2e

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetyl-CoA Carboxylase (ACC)-ACC2 inhibitor 2e

Chemical Structure : ACC2 inhibitor 2e

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货号: PC-73298Not For Human Use, Lab Use Only.

ACC2 inhibitor 2e is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 1.9 nM and 1950 nM for ACC2 and ACC1, respectively.

规格	价格	库存	数量
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250 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ACC2 inhibitor 2e is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 1.9 nM and 1950 nM for ACC2 and ACC1, respectively.
ACC2 inhibitor 2e exhibited good PK profile and in vivo antidiabetic efficacy in C57BL/6 mice.

物理化学性质&存储条件

分子量	417.908
分子式	C20H20ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-N-(4-(6-((7-chloro-2-ethoxybenzo[d]thiazol-6-yl)oxy)pyridin-3-yl)but-3-en-2-yl)acetamide

参考文献

1. Nishiura Y, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503.

2. Takagi H, et al. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263.

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