ACAi-028 | HIV-1 capsid inhibitor | Probechem Biochemicals

Chemical Structure : ACAi-028

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ACAi-028 (ACAi028)

货号: PC-38555Not For Human Use, Lab Use Only.

ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD).

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250 mg		Get quote

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生物&药学活性

ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD).
ACAi-028 binds directly and noncovalently to HIV-1 capsid monomer.
ACAi-028 inhibits the early stage of the HIV-1 life cycle and does not affect the late stage, also prevents multiple-round HIV-1 infection using HIV-1 strains (HIV-1NL4-3 and HIV-1LAI), except for HIV-2 strain (HIV-2ROD).
ACAi-028 inhibits the replication of various types of HIV-1 strains (HIV-1104pre and HIV-1MDR/B) in PBMCs and HIV-1ATVR5μM in MT-4 cells, with negligible cytotoxicity.

物理化学性质&存储条件

分子量	381.204
分子式	C13H9BrN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-bromopyridin-2-yl)carbamothioyl)-2-nitrobenzamide

参考文献

1. Chia T, et al. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0103921.

ACAi-028 (ACAi028)

生物&药学活性

物理化学性质&存储条件

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ACAi-028 (ACAi028)

生物&药学活性

物理化学性质&存储条件

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