AC261066 |CAS:870773-76-5 Probechem Biochemicals

Chemical Structure : AC261066

CAS No.: 870773-76-5

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AC261066 (AC-261066;AC261)

货号: PC-35516Not For Human Use, Lab Use Only.

AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3).

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10 mg	￥1880	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3).
AC261066 exerts cardioprotective effects, also exhibits therapeutic effects in high fat diet (HFD) model of diabetic nephropathy (DN).

物理化学性质&存储条件

分子量	353.408
分子式	C17H20FNO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid

参考文献

1. Lund BW, et al. J Med Chem. 2005 Dec 1;48(24):7517-9.

2. Trasino SE, et al. Diabetes Obes Metab. 2016 Feb;18(2):142-51.

3. Trasino SE, et al. J Mol Med (Berl). 2016 Oct;94(10):1143-1151.

4. Marino A, et al. J Pharmacol Exp Ther. 2018 Aug;366(2):314-321.

AC261066 (AC-261066;AC261)

生物&药学活性

物理化学性质&存储条件

参考文献

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AC261066 (AC-261066;AC261)

生物&药学活性

物理化学性质&存储条件

参考文献

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