AC1Q3QWB | HOTAIR-EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : AC1Q3QWB

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AC1Q3QWB (AQB)

货号: PC-26182Not For Human Use, Lab Use Only.

AC1Q3QWB (ACB) is a selective and efficient inhibitor of HOTAIR-EZH2 interaction with IC50 of 42.47 nM, exhibits potent anti-tumor activity in cancer cells expressing high levels of HOTAIR and EZH2.

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生物&药学活性

AC1Q3QWB (ACB) is a selective and efficient inhibitor of HOTAIR-EZH2 interaction with IC50 of 42.47 nM, exhibits potent anti-tumor activity in cancer cells expressing high levels of HOTAIR and EZH2.
ACB selectively blocks HOTAIR-EZH2 interaction and reduces recruitment of PRC2, does not affect EZH2-binding lincRNAs, including GTL2 10, and H19, also does not affect HOTAIR-chromatin interaction.
AQB can effectively up-regulate both mRNA and protein levels of HOTAIR-PRC2 target genes, suppresses Wnt/β-catenin signaling by upregulating APC2 expression.
AQB (50mg/kg) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic breast cancer model, inhibits tumor cell growth and metastasis in vivo.
Low doses of AQB enhance the efficacy of DZNep resulting from more significant expression of HOTAIR-PRC2 target genes.

物理化学性质&存储条件

分子量	260.16
分子式	C12H15Cl2NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5,7-dichloro-2,3-dihydrobenzofuran-2-yl)methyl)propan-2-amine

参考文献

1. Li Y, et al. Theranostics. 2019 Jun 24;9(16):4608-4623.

2. Shi J, et al. Clin Transl Med. 2020 Jan;10(1):182-198.

3. Tong F, et al. Pharmacol Res. 2023 Jan;187:106606.

AC1Q3QWB (AQB)

生物&药学活性

物理化学性质&存储条件

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AC1Q3QWB (AQB)

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