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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-AC1903
AC1903

Chemical Structure : AC1903

CAS No.: 831234-13-0

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AC1903 (AC-1903)

货号: PC-60025Not For Human Use, Lab Use Only.

AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.

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5 mg ￥380 In stock
10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.
AC1903 blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)-induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations.
AC1903 pecifically blocks TRPC5 channel activity in glomeruli of proteinuric rats, suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of FSGS.

物理化学性质&存储条件

分子量 303.365
分子式 C19H17N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO (30.3 mg/mL)
Chemical Name/SMILES

1-benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine

参考文献

1. Zhou Y, et al. Science. 2017 Dec 8;358(6368):1332-1336.

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