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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Discoidin Domain Receptor (DDR)-AC-4067
AC-4067

Chemical Structure : AC-4067

CAS No.:

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AC-4067 (AC4067)

货号: PC-26310Not For Human Use, Lab Use Only.

AC-4067 is a highly potent, selective inhibitor targeting discoidin domain receptor 1 (DDR1) with IC50 of 30.9 nM, 18-fold selectivity for DDR1 over DDR2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AC-4067 is a highly potent, selective inhibitor targeting discoidin domain receptor 1 (DDR1) with IC50 of 30.9 nM, 18-fold selectivity for DDR1 over DDR2.
AC-4067 boosts WJ-MSC proliferation and scratch-wound closure.
AC-4067 treatment reduces SA-βgal activity and replicative senescence.
AC-4067 suppresses DNA damage by reducing γH2AX levels in late-passage mesenchymal stem cells (MSCs).

物理化学性质&存储条件

分子量 517.47
分子式 C27H18F3N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(1,3-dioxo-5-(pyrimidin-5-ylamino)isoindolin-2-yl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

参考文献

1. Nada H, et al. Biomed Pharmacother. 2026 Mar 6;197:119182.

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