AC-4-130 | STAT5 inhibitor | Probechem Biochemicals

Chemical Structure : AC-4-130

CAS No.: 1834571-82-2

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AC-4-130 (STAT5 inhibitor AC-4-130)

货号: PC-62556Not For Human Use, Lab Use Only.

AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3.
AC-4-130 disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription.
AC-4-130 substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo.
AC-4-130 synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.

物理化学性质&存储条件

分子量	751.206
分子式	C37H36ClF5N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((N-(4-chlorobenzyl)-2,3,4,5,6-pentafluorophenyl)sulfonamido)-N-(3,5-di-tert-butylbenzyl)acetamido)benzoic acid

参考文献

1. Wingelhofer B, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0005-9.

AC-4-130 (STAT5 inhibitor AC-4-130)

生物&药学活性

物理化学性质&存储条件

参考文献

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AC-4-130 (STAT5 inhibitor AC-4-130)

生物&药学活性

物理化学性质&存储条件

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