Obefazimod (ABX464) |CAS:1258453-75-6 Probechem Biochemicals

Chemical Structure : ABX464

CAS No.: 1258453-75-6

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ABX464 (ABX-464, Obefazimod)

货号: PC-36055Not For Human Use, Lab Use Only.

Obefazimod (ABX464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.

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25 mg	￥1380	In stock
50 mg	￥2180	In stock
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生物&药学活性

Obefazimod (ABX464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.
ABX464 inhibits different HIV-1 clades, resistant viruses and did not select for resistance.
ABX464 increases the levels of spliced HIV RNA, influences REV-mediated HIV RNA biogenesis and export, and interacts with the CBC complex.
ABX464 inhibits viral replication in humanized mice.

物理化学性质&存储条件

分子量	338.714
分子式	C16H10ClF3N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

参考文献

1. Campos N, et al. Retrovirology. 2015 Apr 9;12:30.

2. Scherrer D, et al. Antimicrob Agents Chemother. 2016 Dec 27;61(1).

3. Scherrer D, et al. J Antimicrob Chemother. 2017 Mar 1;72(3):820-828.

4. Vautrin A, et al. Sci Rep. 2019 Jan 28;9(1):792.

ABX464 (ABX-464, Obefazimod)

生物&药学活性

物理化学性质&存储条件

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ABX464 (ABX-464, Obefazimod)

生物&药学活性

物理化学性质&存储条件

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