Elcubragistat (ABX1431) | MAGL inhibitor | Probechem Biochemicals

Chemical Structure : ABX-1431

CAS No.: 1446817-84-0

加入收藏

ABX-1431 (ABX1431, Elcubragistat)

货号: PC-35522Not For Human Use, Lab Use Only.

Elcubragistat (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MAGL) with IC50 of 14 nM (hMAGL).

规格	价格	库存
10 mg	￥680	In stock
25 mg	￥1180	In stock
50 mg	￥1780	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Elcubragistat (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MAGL) with IC50 of 14 nM (hMAGL).
Elcubragistat (ABX1431) displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class.
Elcubragistat (ABX1431) inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.

物理化学性质&存储条件

分子量	507.401
分子式	C20H22F9N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1,1,3,3,3-hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

参考文献

1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951.

ABX-1431 (ABX1431, Elcubragistat)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ABX-1431 (ABX1431, Elcubragistat)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.