ABTL0812 |CAS:57818-44-7 Probechem Biochemicals

Chemical Structure : ABTL0812

CAS No.: 57818-44-7

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ABTL0812 (Ibrilatazar, ABTL-0812, 2-hydroxylinoleic acid)

货号: PC-61631Not For Human Use, Lab Use Only.

ABTL0812 (2-hydroxylinoleic acid) is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells, binds to PPARα and PPARγ (Ki=7.1 and 4.7 uM, respectively).

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
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生物&药学活性

ABTL0812 (Ibrilatazar) is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells, binds to PPARα and PPARγ (Ki=7.1 and 4.7 uM, respectively).
ABTL0812 induces PPARα and PPARγ transcriptional activities, and inhibits Akt phosphorylation by upregulating the expression of TRIB3.
ABTL0812 reduces viability of different human cancer cell lines (IC50=20-60 uM), induces autophagy-mediated cell death both in vitro and in vivo.

物理化学性质&存储条件

分子量	296.451
分子式	C18H32O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid

参考文献

1. Erazo T, et al. Clin Cancer Res. 2016 May 15;22(10):2508-19.

ABTL0812 (Ibrilatazar, ABTL-0812, 2-hydroxylinoleic acid)

生物&药学活性

物理化学性质&存储条件

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ABTL0812 (Ibrilatazar, ABTL-0812, 2-hydroxylinoleic acid)

生物&药学活性

物理化学性质&存储条件

参考文献

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