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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-ABT-724
ABT-724

Chemical Structure : ABT-724

CAS No.: 70006-24-5

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ABT-724 (ABT 724, ABT724)

货号: PC-70061Not For Human Use, Lab Use Only.

ABT-724 is a potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ABT-724 is a potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors.
ABT-724 elicits penile erections in rats at a dose of 0.03 uMl/kg, increases intracavernosal pressure in awake freely moving rats.

物理化学性质&存储条件

分子量 293.366
分子式 C17H19N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole

参考文献

1. Brioni JD, et al. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63.

2. Cowart M, et al. J Med Chem. 2004 Jul 15;47(15):3853-64.

3. Yin P, et al. Neurosci Lett. 2014 Sep 19;580:142-6.

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