ABT-702 dihydrochloride | Adenosine kinase inhibitor | Probechem Biochemicals

Chemical Structure : ABT-702 dihydrochloride

CAS No.: 1188890-28-9

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ABT-702 dihydrochloride (ABT702)

货号: PC-38791Not For Human Use, Lab Use Only.

ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.
ABT-702 displays several orders of magnitude selectivity over other sites of ADO interaction (A(1), A(2A), A(3) receptors, ADO transporter, and ADO deaminase), and 1300- to 7700-fold selective for ADK compared with a number of other neurotransmitter and peptide receptors, ion channel proteins, neurotransmitter/nucleoside reuptake sites, and enzymes, including COX-1 and -2.
ABT-702 is orally active and fully efficacious in reducing acute somatic nociception (ED50 = 8 micromol/kg i.p.; 65 micromol/kg p.o.) in the mouse hot-plate assay.
ABT-702 also dose dependently reduced nociception in the phenyl-p-quinone-induced abdominal constriction assay.
ABT-702 dispalyed analgesic and anti-inflammatory properties in vivo.

物理化学性质&存储条件

分子量	536.25
分子式	C22H21BrCl2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride

参考文献

1. Kowaluk EA, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.

2. Lee CH, et al. J Med Chem. 2001 Jun 21;44(13):2133-8.

3. Suzuki R, et al. Br J Pharmacol. 2001 Apr;132(7):1615-23. al.

4. Jarvis MF, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.

ABT-702 dihydrochloride (ABT702)

生物&药学活性

物理化学性质&存储条件

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ABT-702 dihydrochloride (ABT702)

生物&药学活性

物理化学性质&存储条件

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