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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Adenosine Kinase (AdK)-ABT-702
ABT-702

Chemical Structure : ABT-702

CAS No.: 214697-26-4

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ABT-702 (ABT702)

货号: PC-38790Not For Human Use, Lab Use Only.

ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.
ABT-702 displays several orders of magnitude selectivity over other sites of ADO interaction (A(1), A(2A), A(3) receptors, ADO transporter, and ADO deaminase), and 1300- to 7700-fold selective for ADK compared with a number of other neurotransmitter and peptide receptors, ion channel proteins, neurotransmitter/nucleoside reuptake sites, and enzymes, including COX-1 and -2.
ABT-702 is orally active and fully efficacious in reducing acute somatic nociception (ED50 = 8 micromol/kg i.p.; 65 micromol/kg p.o.) in the mouse hot-plate assay.
ABT-702 also dose dependently reduced nociception in the phenyl-p-quinone-induced abdominal constriction assay.
ABT-702 dispalyed analgesic and anti-inflammatory properties in vivo.

物理化学性质&存储条件

分子量 463.339
分子式 C22H19BrN6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyrido[2,3-d]pyrimidin-4-amine, 5-(3-bromophenyl)-7-[6-(4-morpholinyl)-3-pyridinyl]-

参考文献

1. Kowaluk EA, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.

2. Lee CH, et al. J Med Chem. 2001 Jun 21;44(13):2133-8.

3. Suzuki R, et al. Br J Pharmacol. 2001 Apr;132(7):1615-23. al.

4. Jarvis MF, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.

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