ABT-639 |CAS:1235560-28-7 Probechem Biochemicals

Chemical Structure : ABT-639

CAS No.: 1235560-28-7

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ABT-639 (ABT639;ABT 639)

货号: PC-45686Not For Human Use, Lab Use Only.

ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM).

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM).
ABT-639 attenuates LVA currents in rat DRG neurons (IC50=8 uM).
ABT-639 is less active at other Ca2+ channels (IC50> 30 uM).
ABT-639 effectively reduces nociceptive and neuropathic pain in rats; high oral bioavailability.

物理化学性质&存储条件

分子量	455.9059
分子式	C20H20ClF2N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-

参考文献

1. Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15;89(4):536-44.

2. Teleb M, et al. Bioorg Med Chem. 2017 Mar 15;25(6):1926-1938.

3. Serra J, et al. Pain. 2015 Nov;156(11):2175-83.

ABT-639 (ABT639;ABT 639)

生物&药学活性

物理化学性质&存储条件

参考文献

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ABT-639 (ABT639;ABT 639)

生物&药学活性

物理化学性质&存储条件

参考文献

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