ABT-418 | nAChR activator | Probechem Biochemicals

Chemical Structure : ABT-418

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ABT-418 (ABT418)

货号: PC-20544Not For Human Use, Lab Use Only.

ABT-418 (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM.

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生物&药学活性

ABT-418 (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM.
ABT-418 is inactive (Ki > 10,000 nM) in 37 other receptor/neurotransmitter-uptake/enzyme/transduction system binding assays.
ABT-418 is also approximately 10-fold less potent (EC50 value=380 nM) than (-)-nicotine (40 nM) in increasing [3H]-dopamine release from rat striatal slices.
ABT-418 (MED, 0.002 mumol/kg i.v.) is remarkably potent in enhancing basal forebrain-elicited increases in cortical cerebral blood flow in rats.
ABT-418 demonstrates potent cognitive-enhancing and anxiolytic properties in animal models without eliciting significant side effects.

物理化学性质&存储条件

分子量	166.22
分子式	C9H14N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CN1[C@H](C2=CC(C)=NO2)CCC1

参考文献

1. Arneric SP, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):310-8.

2. Decker MW, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28.

ABT-418 (ABT418)

生物&药学活性

物理化学性质&存储条件

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ABT-418 (ABT418)

生物&药学活性

物理化学性质&存储条件

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