ABT-089 |CAS:161417-03-4 Probechem Biochemicals

Chemical Structure : ABT-089

CAS No.: 161417-03-4

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ABT-089 (ABT089;Pozanicline)

货号: PC-61619Not For Human Use, Lab Use Only.

ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM.

规格	价格	库存
25 mg	￥1980	In stock
100 mg	￥4980	In stock
200 mg	￥7580	In stock
1 g		Get quote

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生物&药学活性

ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR.
ABT-089 displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM).
ABT-089 shows effects on cognitive performance in rats and monkeys.

物理化学性质&存储条件

分子量	178.231
分子式	C11H16N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine

参考文献

1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90.

2. Sullivan JP, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46.

3. Decker MW, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58.

ABT-089 (ABT089;Pozanicline)

生物&药学活性

物理化学性质&存储条件

参考文献

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ABT-089 (ABT089;Pozanicline)

生物&药学活性

物理化学性质&存储条件

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