ABT-080 |CAS:189498-57-5 Probechem Biochemicals

Chemical Structure : ABT-080

CAS No.: 189498-57-5

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ABT-080 (VML-530, ABT080)

货号: PC-35037Not For Human Use, Lab Use Only.

ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.

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10 mg	￥2480	In stock
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生物&药学活性

ABT-080 (VML-530) is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.
ABT-080 selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing.
ABT-080 demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model.

物理化学性质&存储条件

分子量	590.655
分子式	C37H31N2NaO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4-Bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt

参考文献

1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34.

ABT-080 (VML-530, ABT080)

生物&药学活性

物理化学性质&存储条件

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ABT-080 (VML-530, ABT080)

生物&药学活性

物理化学性质&存储条件

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