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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-NEDD8-ABP-A3
ABP-A3

Chemical Structure : ABP-A3

CAS No.: 2764990-15-8

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ABP-A3 (ABP A3)

货号: PC-60350Not For Human Use, Lab Use Only.

ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.
    ABP-A3 inhibits conjugation of ubiquitin to intracellular proteins and prevents the formation of cytoprotective aggresomes.
    ABP-A3 induces activation of the unfolded protein response (UPR) and apoptosis, displays IC50 of 2.5 uM in cell viability assays in A549 cells.

    物理化学性质&存储条件

    分子量 446.438
    分子式 C18H18N6O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((2R,3S,4R,5R)-5-(6-((4-ethynylphenyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate

    参考文献

    1. An H, et al. Chem Sci. 2015 Sep 1;6(9):5235-5245.

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