ABL127 (ML174) | PME-1 inhibitor | Probechem Biochemicals

Chemical Structure : ABL127

CAS No.: 1073529-41-5

加入收藏

ABL127 (AB L127, ML174)

货号: PC-63266Not For Human Use, Lab Use Only.

ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM.
ABL127 (ML174) shows IC50s of 6.4 nM and 4.2 nM in HEK293T and MDA-MB-231 cells, respectively, decreases cell proliferation and invasive growth in vitro.
ABL127 (ML174) shows selectivity at 1 uM against 30 serine hydrolase anti-targets.
ABL127 (ML174) is highly active against PME-1 and can cause 85% reduction of demethylated PP2A, demonstrates greater potential for use in long time-course in situ studies.

物理化学性质&存储条件

分子量	332.356
分子式	C17H20N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylate

参考文献

1. Pusey M, et al. Tumour Biol. 2016 Sep;37(9):11835-11842.

2. Bachovchin DA, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6.

3. Bachovchin DA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ABL127 (AB L127, ML174)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ABL127 (AB L127, ML174)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.