ABH hydrochloride

Chemical Structure : ABH hydrochloride

CAS No.: 194656-75-2

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货号: PC-70087Not For Human Use, Lab Use Only.

ABH hydrochloride is a potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ABH hydrochloride is a potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase.
ABH hydrochloride inhibits the LPS-induced increases in pulmonary IL-8, neutrophils, and goblet cells as well as airway fibrosis.
ABH hydrochloride prevents LPS-induced right ventricular hypertrophy, indicative of pulmonary hypertension in a guinea pig model of COPD.

物理化学性质&存储条件

分子量	211.45
分子式	C6H14BNO4 · HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-6-boronohexanoic acid hydrochloride

参考文献

1. Colleluori DM, et al. Biochemistry. 2001 Aug 7;40(31):9356-62.

2. Baggio R, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):1409-16.

3. Pera T, et al. J Pharmacol Exp Ther. 2014 May;349(2):229-38.