ABD345 | RANKL inhibitor | Probechem Biochemicals

Chemical Structure : ABD345

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ABD345 (ABD-345, ABD 345)

货号: PC-63339Not For Human Use, Lab Use Only.

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.

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生物&药学活性

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
ABD345 inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7 uM) without any effects on bone marrow macrophage viability.
ABD345 inhibits RANKL-induced phosphorylation of IκB and ERK in M-CSF-dependent bone marrow macrophage cultures.
ABD345 inhibits both RANKL- and TNF-induced NF-κB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.

物理化学性质&存储条件

分子量	318.364
分子式	C19H20F2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2',4'-Difluoro-2-methyl[1,1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone

参考文献

1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.

ABD345 (ABD-345, ABD 345)

生物&药学活性

物理化学性质&存储条件

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ABD345 (ABD-345, ABD 345)

生物&药学活性

物理化学性质&存储条件

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