ABD-1970 (ABD1970) | MAGL inhibitor | Probechem Biochemicals

Chemical Structure : ABD-1970

加入收藏

ABD-1970 (ABD1970, ABD 1970)

货号: PC-35714Not For Human Use, Lab Use Only.

ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MAGL) inhibitor with IC50 of 13 nM (human MAGL).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MAGL) inhibitor with IC50 of 13 nM (human MAGL).
ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg).
ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production.

物理化学性质&存储条件

分子量	515.881
分子式	C21H24ClF6N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(8-oxa3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzyl)piperazine-1-carboxylate

参考文献

1. Clapper JR, et al. J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296.

ABD-1970 (ABD1970, ABD 1970)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ABD-1970 (ABD1970, ABD 1970)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.