ABC1183 | GSK3/CDK9 inhibitor | Probechem Biochemicals

Chemical Structure : ABC1183

CAS No.: 1042735-18-1

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ABC1183 (ABC-1183)

货号: PC-62530Not For Human Use, Lab Use Only.

ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines.
ABC1183 decreases cell survival through G2/M arrest and modulates oncogenic signaling through changes in GSK3, GS and β-catenin phosphorylation and MCL1 expression.
ABC1183 suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms without organ or hematological toxicity in vivo.

物理化学性质&存储条件

分子量	334.397
分子式	C18H14N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile

参考文献

1. Schrecengost RS, et al. J Pharmacol Exp Ther. 2018 Feb 6. pii: jpet.117.245738.

ABC1183 (ABC-1183)

生物&药学活性

物理化学性质&存储条件

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ABC1183 (ABC-1183)

生物&药学活性

物理化学性质&存储条件

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