ABBV-712 | TYK2-JH2 inhibitor | Probechem Biochemicals

Chemical Structure : ABBV-712

CAS No.: 2368945-27-9

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ABBV-712 (ABBV712, ABBV 712)

货号: PC-21236Not For Human Use, Lab Use Only.

ABBV-712 is a potent, selective inhibitor of tyrosine kinase 2 (TYK2) with EC50 of 0.01 uM, binds and stabilizes the pseudokinase (JH2) domain of TYK2.

规格	价格	库存
2 mg	￥2580	In stock
5 mg	￥3980	In stock
10 mg	￥5780	In stock
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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ABBV-712 is a potent, selective inhibitor of tyrosine kinase 2 (TYK2) with EC50 of 0.01 uM, binds and stabilizes the pseudokinase (JH2) domain of TYK2.
ABBV-712 exhibits desired TYK2 cell potency (EC50=0.19 uM) and exquisite selectivity against other JAK family members (>20 μM in cellular assays.
ABBV-712 (100, 300, and 600 mg/kg) dose-dependently inhibited IFN-γ production in IL-12/IL-18-induced IFN-γ mouse model, dose-dependently decreases ear thickness in mouse IL-23 minicircle-induced ear dermatitis model.

物理化学性质&存储条件

分子量	452.51
分子式	C24H28N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-(4-(Methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-(oxetan-3-yl)-1H-pyrrolo[2,3-c]pyridin-5-yl)acetamide

参考文献

1. Breinlinger E, et al. J Med Chem. 2023 Oct 12. doi: 10.1021/acs.jmedchem.3c01373.

ABBV-712 (ABBV712, ABBV 712)

生物&药学活性

物理化学性质&存储条件

参考文献

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ABBV-712 (ABBV712, ABBV 712)

生物&药学活性

物理化学性质&存储条件

参考文献

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