ABBV-552 (SDI-118) | SV2A modulator | Probechem Biochemicals

Chemical Structure : ABBV-552

加入收藏

ABBV-552 (SDI-118, ABBV552)

货号: PC-27727Not For Human Use, Lab Use Only.

ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A).
ABBV-552 (SDI-118) has high selectivity over other SV2 isoforms, SV2B (over 1000-fold) and SV2C (over 100-fold).
ABBV-552 (SDI-118) enhances synaptic efficiency by increasing presynaptic neurotransmitter release.
ABBV-552 (SDI-118) shows promising cognitive function improvement in some neurological disorders.

物理化学性质&存储条件

分子量	330.70
分子式	C13H10ClF3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-((5-chloro-1H-1,2,4-triazol-1-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one

参考文献

1. Botermans W, et al. Front Pharmacol. 2023 Jan 17;13:1066447.

2. Miles N, et al. Eur J Clin Pharmacol. 2026 Jul 21;82(8):214.

ABBV-552 (SDI-118, ABBV552)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ABBV-552 (SDI-118, ABBV552)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.