ABBV-105 |CAS: 1643570-24-4 Probechem Biochemicals

Chemical Structure : ABBV-105

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ABBV-105 (Elsubrutinib, ABBV105)

货号: PC-35203Not For Human Use, Lab Use Only.

ABBV-105 (ABBV105) is a potent, selective, irreversible, covalent inhibitor of BTK with IC50 of 0.18 uM.

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生物&药学活性

ABBV-105 (Elsubrutinib, ABBV105) is a potent, selective, irreversible, covalent inhibitor of BTK with IC50 of 0.18 uM.
ABBV-105 irreversibly inhibits BTK, demonstrating superior kinome selectivity and is potent in B cell receptor, Fc receptor, and TLR-9-dependent cellular assays.
ABBV-105 inhibits antibody responses to thymus-independent and thymus-dependent antigens, paw swelling and bone destruction in rat collagen induced arthritis (CIA), and reduces disease in an IFNα-accelerated lupus nephritis model.

物理化学性质&存储条件

分子量	297.36
分子式	C17H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-7-carboxamide, 4-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-

参考文献

1. Goess C, et al. Mod Rheumatol. 2018 Jun 2:1-32. doi: 10.1080/14397595.2018.1484269.

ABBV-105 (Elsubrutinib, ABBV105)

生物&药学活性

物理化学性质&存储条件

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ABBV-105 (Elsubrutinib, ABBV105)

生物&药学活性

物理化学性质&存储条件

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