ABA receptor agonist iCB

Chemical Structure : ABA receptor agonist iCB

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货号: PC-25170Not For Human Use, Lab Use Only.

ABA receptor agonist iCB is a novel synthetic abscisic acid (ABA) receptor agonist with broad-spectrum activation across the three receptor subtypes, has IC50 of 0.16 uM in seedling establishment inhibition assay.

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生物&药学活性

ABA receptor agonist iCB is a novel synthetic abscisic acid (ABA) receptor agonist with broad-spectrum activation across the three receptor subtypes, has IC50 of 0.16 uM in seedling establishment inhibition assay.
iCB shows a significantly higher inhibition of germination than Cyanabactin (CB) and ABA in seeds.
iCB is active in inhibiting seedling establishment 7 days after sowing, iCB showed long-lasting effects, and iCB (2 uM) inhibits early seedling growth after 22 days.
Dimeric receptors (i.e., PYR1, PYL1, PYL2) appears more critical than monomeric ones to mediate the iCB-dependent inhibition in seedling establishment assays.
iCB is a broad-spectrum agonist with nanomolar affinity for receptor-phosphatase complexes.
iCB shows activity against dimeric and PYL4/PYL5 receptors, is more active than CB against subfamily I receptors, i.e., PYL8 and PYL9.
iCB binds with a higher affinity than ABA to clade III receptor-phosphatase complexes.

物理化学性质&存储条件

分子量	326.41
分子式	C18H18N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-cyano-3-cyclopropylbenzyl)-4 methylbenzenesulfonamide

参考文献

1. Mar Bono, et al. Mol Plant. 2025 Jul 25:S1674-2052(25)00243-6.