AB928 |CAS: 2239273-34-6 Probechem Biochemicals

Chemical Structure : AB928

CAS No.: 2239273-34-6

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AB928 (Etrumadenant;AB-928;AB 928)

货号: PC-35841Not For Human Use, Lab Use Only.

Etrumadenant (AB928) is a potent, dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

Etrumadenant (AB928) is a potent, dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively.
AB928 displays high selectivity towards related receptors (A1R, A3R, CD73, CD39, NTPDase 2/3).
AB928 is a potent inhibitor of NECA-mediated A2aR activation on cell lines, potently reverses adenosine-mediated CD8+ T cell suppression, potently inhibits cAMP-mediated pCREB activation in human leukocyte populations in whole blood.
AB928 inhibits tumor micro-environment adenosine generation and signaling for the treatment of cancer.

物理化学性质&存储条件

分子量	426.484
分子式	C23H22N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

参考文献

1, Seitz L, et al. Invest New Drugs. 2019 Aug;37(4):711-721.

AB928 (Etrumadenant;AB-928;AB 928)

生物&药学活性

物理化学性质&存储条件

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AB928 (Etrumadenant;AB-928;AB 928)

生物&药学活性

物理化学性质&存储条件

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