AB8939 | Tubulin polymerization inhibitor | Probechem Biochemicals

Chemical Structure : AB8939

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AB8939 (AB-8939)

货号: PC-25068Not For Human Use, Lab Use Only.

AB8939 is a next-generation small-molecule tubulin polymerization inhibitor, binds to tubulin and induces a rapid destabilisation of microtubules.

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生物&药学活性

AB8939 is a next-generation small-molecule tubulin polymerization inhibitor, binds to tubulin and induces a rapid destabilisation of microtubules.
AB8939 shows broad anti-proliferative activity across the breath of acute myeloid leukemia (AML) subtypes.
AB8939 produces a strong anti-proliferative action against blasts isolated from AML patients with a majority of IC50 values ranging from 1.4 nM to 1.0 µM.
AB8939 demonstrates activity across the entire spectrum of AML subtypes, according to the French-American-British (FAB) AML classification, with an IC50 of < 50 nM in M0, M1, M4, M5 and M6 subtypes, corresponding to over 90% of the AML patient population.
AB8939 showed strong anti-leukemic activity in AMKL26 mouse model as evidenced by the near eradication of blasts.

物理化学性质&存储条件

分子量
分子式	C22H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Imidazolidinone, 1-[4-[2-[[5-(ethoxymethyl)-2-methylphenyl]amino]-5-oxazolyl]phenyl]-

参考文献

1. Armelle Goubard, et al. Blood (2019) 134 (Supplement_1): 5154.

AB8939 (AB-8939)

生物&药学活性

物理化学性质&存储条件

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AB8939 (AB-8939)

生物&药学活性

物理化学性质&存储条件

参考文献

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