AB-161 | PAPD5/7 inhibitor | Probechem Biochemicals

Chemical Structure : AB-161

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AB-161 (AB161)

货号: PC-23459Not For Human Use, Lab Use Only.

AB-161 is a potent, selective and orally bioavailable PAPD5/7 inhibitor (IC50=0.85/1.1 uM) and HBV RNA destabilizer with EC50 of 2.2 nM for reduction of HBsAg in HepG2.2.15 cells.

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生物&药学活性

AB-161 is a potent, selective and orally bioavailable PAPD5/7 inhibitor (IC50=0.85/1.1 uM) and HBV RNA destabilizer with EC50 of 2.2 nM for reduction of HBsAg in HepG2.2.15 cells.
AB-161 reduces HBsAg, HBeAg, and HBV DNA production with EC50 values ranging between 8.5 and 12 nM in primary human hepatocytes (PHH) infected with HBV.
AB-161 is inactive against a panel of ten RNA and DNA viruses (EC50 > 30 μM) displaying selectivity for HBV > 10,000-fold with no appreciable toxicity in cells derived from different tissues (CC50 > 30 μM).
AB-161 also inhibits multiple stages of the HBV life cycle including HBV pgRNA, preS/S RNA, HBV core and capsids, and replicating HBV DNA.

物理化学性质&存储条件

分子量	433.41
分子式	C21H21F2N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5- h]quinoline-3-carboxylic Acid

参考文献

1. Gotchev D, et al. J Med Chem. 2024 Nov 8. doi: 10.1021/acs.jmedchem.4c01928.

AB-161 (AB161)

生物&药学活性

物理化学性质&存储条件

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AB-161 (AB161)

生物&药学活性

物理化学性质&存储条件

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