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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-AB-00011778
AB-00011778

Chemical Structure : AB-00011778

CAS No.: 1037551-68-0

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AB-00011778 (AB00011778)

货号: PC-49258Not For Human Use, Lab Use Only.

AB-00011778 is a small molecule inhibitor of SARS-CoV-2 entry and the Spike/ACE2 interaction, inhibits viral replication with EC50 of 250 nM in A549-ACE2 cells, AB-00011778 is equally effective in impairing the S/ACE2 association in the different mutants.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AB-00011778 is a small molecule inhibitor of SARS-CoV-2 entry and the Spike/ACE2 interaction, inhibits viral replication with EC50 of 250 nM in A549-ACE2 cells, AB-00011778 is equally effective in impairing the S/ACE2 association in the different mutants.
    AB-00011778 interferes with the formation of the RBD/ACE2 complex, reaching 50% inhibition at 25 uM in AlphaLISA assays.
    AB-00011778 inhibits the binding of S-RBD(His)6 to ACE2 with KD of 111 nM in biolayer interferometry (BLI) assays.
    AB-00011778 blocks the viral replication of four major circulating forms of SARS-CoV-2 (the original Wuhan strain and the alpha, delta, and omicron viruses) in pulmonary A549-ACE2 cells with IC50 of 0.5-1 uM, with cytotoxic concentration (CC50) values >30 uM.

    物理化学性质&存储条件

    分子量 801.932
    分子式 C47H35N3O6S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,5-bis(5-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)pyridine

    参考文献

    1. Delphine Lapaillerie, et al. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0008322.

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