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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-AAPK-25
AAPK-25

Chemical Structure : AAPK-25

CAS No.: 2247919-28-2

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AAPK-25 (AAPK25)

货号: PC-24004Not For Human Use, Lab Use Only.

AAPK-25 is a small molecule inhibitor of DLGAP5 with a binding energy of −9.2 Kcal/mol, suppresses proliferation of PRAD cells via inhibiting DLGAP5/E2F1 axis, also is a potent, dual Aurora/PLK coinhibitor.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AAPK-25 is a small molecule inhibitor of DLGAP5 with a binding energy of −9.2 Kcal/mol, suppresses proliferation of PRAD cells via inhibiting DLGAP5/E2F1 axis, also is a potent, dual Aurora/PLK coinhibitor.
AAPK-25 effectively inhibited the proliferation of PC3 and DU145 cells with IC50 of 467 nM and 356 nM respectively.
40 nM AAPK-25 significantly hindered the colony formation ability of LNCaP and C4–2 cells, downregulated DLGAP5, E2F1, and ENO2.
AAPK-25 (25 mg/kg) suppresses tumor growth and DLGAP5/E2F1 pathway in murine PRAD xenograft model using BALB/c nude mice bearing PC3 cells.

物理化学性质&存储条件

分子量 442.31
分子式 C21H13Cl2N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(3,4-dichlorobenzamido)-N-(thiazol-2-yl)-2-naphthamide

参考文献

1. Liang L, et al. Life Sci. 2025 Feb 7:123442.

2. Qi B, et al. J Med Chem. 2019 Sep 12;62(17):7697-7707.

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