AAP-SO2

Chemical Structure : AAP-SO2

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货号: PC-26173Not For Human Use, Lab Use Only.

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生物&药学活性

AAP-SO2 is highly potent Mycobacterium tuberculosis (Mtb) RNA polymerase (RNAP) inhibitor with IC50 of 25 nM using an aptamer-based in vitro transcription assay, inhibits nucleotide addition, thereby reducing elongation and increasing termination rates.
AAP-SO2 directly bind Mtb RNAP and inhibits nucleotide addition.
AAP-SO2 shows increased activity against βS450L Mtb and slows the evolution of rifampicin resistance.
AAP-SO2 effectively kills replicating and non-replicating Mtb, kills non-replicating Mtb at a caseum minimal bactericidal concentration (casMBC90) of 7.89 μM.
Combination treatment with rifampicin and AAP-SO2 synergistically killed non-replicating Mtb in an ex vivo rabbit granuloma model.

物理化学性质&存储条件

分子量	495.57
分子式	C26H26FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-((2-(1,1-dioxidothiomorpholino)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-fluorobenzamide

参考文献

1. Bosch B, et al. Nat Microbiol. 2025 Dec 3. doi: 10.1038/s41564-025-02201-6.

AAP-SO2

生物&药学活性

物理化学性质&存储条件

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AAP-SO2

生物&药学活性

物理化学性质&存储条件

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