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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-AAL993
AAL993

Chemical Structure : AAL993

CAS No.: 269390-77-4

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AAL993 (AAL 993;ZK260253)

货号: PC-63214Not For Human Use, Lab Use Only.

AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively.

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10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively。
AAL993 (ZK260253) dose-dependently inhibits tumor growth in nude mice bearing human prostate carcinoma (DU145) subcutaneous xenografts。
AAL993 (ZK260253) possesses dual functions: inhibition of VEGFR signaling and HIF-1alpha expression under the hypoxic condition, suppresses HIF-1alpha expression through ERK inhibition without affecting Akt phosphorylation.

物理化学性质&存储条件

分子量 371.363
分子式 C20H16F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((pyridin-4-ylmethyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide

参考文献

1. Ban HS, et al. Cancer Lett. 2010 Oct 1;296(1):17-26.

2. Honda T, et al. Bioorg Med Chem Lett. 2008 May 1;18(9):2939-43.

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