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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-AAL-149
AAL-149

Chemical Structure : AAL-149

CAS No.: 177258-60-5

AAL-149 (AAL149)

货号: PC-21131Not For Human Use, Lab Use Only.

AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo.
AAL-149 inhibit LPS-induced inflammatory gene expression in macrophages and microglia.

物理化学性质&存储条件

分子量 293.45
分子式 C18H31NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-amino-4-(4-(heptyloxy)phenyl)-2-methylbutan-1-ol

参考文献

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