AAK1 inhibitor (S)-31

Chemical Structure : AAK1 inhibitor (S)-31

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货号: PC-20650Not For Human Use, Lab Use Only.

AAK1 inhibitor (S)-31 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 5.8 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AAK1 inhibitor (S)-31 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 5.8 nM.
AAK1 inhibitor (S)-31 displays 25-fold selectivity over BIKE (IC50 = 0.161 uM), and good kinase selectivity against in-house panel of kinases.
AAK1 inhibitor (S)-31 (30 mg/kg, sc) effectively reduced μ2 phosphorylation in C57BL6 mice.
AAK1 inhibitor (S)-31 exhibited improved enzyme and cellular potency compared to BMS-911172.

物理化学性质&存储条件

分子量	316.41
分子式	C20H20N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(1-Amino-3-methylbutyl)-6-(pyridin-4-yl)quinoline-4-carbonitrile

参考文献

1. Richard A Hartz, et al. J Med Chem. 2022 Mar 10;65(5):4121-4155.