AAE871 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : AAE871

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AAE871 (AAE 871, AAE-871)

货号: PC-35272Not For Human Use, Lab Use Only.

AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity.

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生物&药学活性

AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity.

物理化学性质&存储条件

分子量	498.65
分子式	C24H34N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-((1r,4r)-4-aminocyclohexyl)-9-ethyl-N6-(4-(piperidin-1-ylsulfonyl)phenyl)-9H-purine-2,6-diamine

参考文献

1. Weisberg E, et al. Genes Cancer. 2010 Oct;1(10):1021-32.

AAE871 (AAE 871, AAE-871)

生物&药学活性

物理化学性质&存储条件

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AAE871 (AAE 871, AAE-871)

生物&药学活性

物理化学性质&存储条件

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