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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclooxygenase (COX)-AA520
AA520

Chemical Structure : AA520

CAS No.: 1904607-15-3

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AA520 (AA-520)

货号: PC-23590Not For Human Use, Lab Use Only.

AA520 is a potent, dual inhibitor of cyclooxygenase-2 (COX-2) and PPARα with IC50 of 0.1 uM (inhibition of LPS-induced PGE2).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AA520 is a potent, dual inhibitor of cyclooxygenase-2 (COX-2) and PPARα with IC50 of 0.1 uM (inhibition of LPS-induced PGE2).
AA520 dispays exquisite selectivity on PPARα concerning PPARγ, and 697-fold selective over COX-1.
AA520 does not affect LPS-induced monocyte COX-2 expression, and other eicosanoids generated by enzymatic and nonenzymatic pathways.
AA520 inhibited COX-2-dependent PGE2 generation in the colon cancer cell line HCA7. AA520 (1 μM) significantly reduced MTT in HCA7 cells.

物理化学性质&存储条件

分子量 500.99
分子式 C25H25ClN2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-N-(4-((2-methyl-1-oxo-1-(phenylsulfonamido)propan-2-yl)oxy)phenethyl)benzamide

参考文献

1. Ammazzalorso A, et al. Front Pharmacol. 2024 Nov 26;15:1488722.

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