AA132 | UPR activator | Probechem Biochemicals

Chemical Structure : AA132

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AA132 (AA-132)

货号: PC-49720Not For Human Use, Lab Use Only.

AA132 (AA-132) is a small molecule activator of UPR signaling, covalently modifies a subset of ER protein disulfide isomerases (PDIs), activates global UPR signaling through a mechanism analogous to that of AA147.

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生物&药学活性

AA132 (AA-132) is a small molecule activator of UPR signaling, covalently modifies a subset of ER protein disulfide isomerases (PDIs), activates global UPR signaling through a mechanism analogous to that of AA147.
AA132 showed reduced selectivity for ATF6 transcriptional program activation in comparison to AA147, instead AA132 globally activates all three UPR signaling pathways.
AA132 covalently modifies PDIs to a greater extent than AA147.
AA132 globally activates the UPR through increased engagement of ER PDIs.

物理化学性质&存储条件

分子量	271.29
分子式	C16H14FNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-fluorophenyl)-3-((2-hydroxy-5-methylphenyl)amino)prop-2-en-1-one

参考文献

1. Gabriel M Kline, et al. bioRxiv. 2023 Jan 17;2023.01.16.524237.

AA132 (AA-132)

生物&药学活性

物理化学性质&存储条件

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AA132 (AA-132)

生物&药学活性

物理化学性质&存储条件

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