AA-CW236 |CAS:1869921-96-9 Probechem Biochemicals

Chemical Structure : AA-CW236

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AA-CW236 (AA-CW-236;AA-CW 236)

货号: PC-61160Not For Human Use, Lab Use Only.

AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.

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生物&药学活性

AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.
AA-CW236 exhibits a high degree of selectivity towards MGMT.
AA-CW236 strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay.

物理化学性质&存储条件

分子量	400.786
分子式	C17H16ClF3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole

参考文献

1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5.

AA-CW236 (AA-CW-236;AA-CW 236)

生物&药学活性

物理化学性质&存储条件

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AA-CW236 (AA-CW-236;AA-CW 236)

生物&药学活性

物理化学性质&存储条件

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