A 83-01 | TGF-βRI inhibitor | Probechem Biochemicals

Chemical Structure : A 83-01

CAS No.: 909910-43-6

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A 83-01 (A83-01, A-83-01)

货号: PC-42582Not For Human Use, Lab Use Only.

A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
A 83-01 dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3.
A 83-01 prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.

物理化学性质&存储条件

分子量	421.5168
分子式	C25H19N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-

参考文献

1. Tojo M, et al. Cancer Sci. 2005 Nov;96(11):791-800.

2. Yuan X, et al. Stem Cells. 2011 Mar;29(3):549-53.

3. Yamamura S, et al. Int J Cancer. 2012 Jan 1;130(1):20-8.

4. Minowa T, et al. Br J Cancer. 2009 Dec 1;101(11):1884-90.

A 83-01 (A83-01, A-83-01)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

A 83-01 (A83-01, A-83-01)

生物&药学活性

物理化学性质&存储条件

参考文献

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