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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-A8-A2
A8-A2

Chemical Structure : A8-A2

CAS No.: 709004-04-6

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A8-A2 (PRRS NendoU inhibitor)

货号: PC-23811Not For Human Use, Lab Use Only.

A8-A2 is a specific small molecule inhibitor of PRRSV NSP11 nidoviral uridylate-specific endoribonuclease (NendoU) domain, shows broad-spectrum antiviral avitivity against nidoviruses.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A8-A2 is a specific small molecule inhibitor of PRRSV NSP11 nidoviral uridylate-specific endoribonuclease (NendoU) domain, shows broad-spectrum antiviral avitivity against nidoviruses.
A8-A2 shows inhibitory effects on both VR- and LY-NSP11 activities at a concentration of 15 µM, with IC50 of 23.0 and 24.6 µM for LY- and VR-NSP11, respectively, in the NendoU assay at 2 h.
A8-A2 (30 uM, 50 uM) significantly reduced PRRSV RNA levels across all five strains with EC90 values of 10.00-17.92 µM.
A8-A2 exhibits a broad-spectrum antiviral agent against nidoviruses, supporting its therapeutic application for infections beyond PRRSV.
A8-A2 not only inhibits direct viral replication but also reactivates the cellular IFN-I response through the inhibition of NendoU activity.
The antiviral activity of A8-A2 is independent of mRNA splicing inhibition.

物理化学性质&存储条件

分子量 325.37
分子式 C17H19N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-ethyl-2-((7-methoxy-4-methylquinazolin-2-yl)amino)-6-methylpyrimidin-4(3H)-one

参考文献

1. Zhu J, et al. J Virol. 2024 Dec 31:e0203424.

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