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首页-小分子抑制剂&激动剂-GPCR-Angiotensin Receptor-A779
A779

Chemical Structure : A779

CAS No.: 159432-28-7

A779 (A-779)

货号: PC-21224Not For Human Use, Lab Use Only.

A779 is a potent, selective antagonist of angiotensin-(1-7) receptor Mas, blocks the antidiuretic effect of Ang-(1-7) in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A779 is a potent, selective antagonist of angiotensin-(1-7) receptor Mas, blocks the antidiuretic effect of Ang-(1-7) in vivo.
A779 inhibited antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral medulla.
A-779 did not change the dipsogenic, pressor, or myotropic effects of angiotensin II (Ang II).
A-779 did not affect the antidiuretic effect of vasopressin or the contractile effects of angiotensin III, bradykinin, or substance P on the rat ileum.

物理化学性质&存储条件

分子量 872.97
分子式 C39H60N12O11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-L-Isoleucine-7-D-alanine-1-7-angiotensin II

参考文献

1. Santos RA, et al. Brain Res Bull. 1994;35(4):293-8.

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