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首页-小分子抑制剂&激动剂-GPCR-Cholecystokinin Receptor-A71623
A71623

Chemical Structure : A71623

CAS No.: 130408-77-4

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A71623 (A-71623)

货号: PC-22020Not For Human Use, Lab Use Only.

A-71623 (A71623) is a cholecystokinin tetrapeptide (30-33) analogue as potent, highly selective CCK-A (CCK1) cholecystokinin receptor agonist with binding IC50 of 3.7 nM, >1000-fold selective over CCK-B receptor.

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2 mg ￥3980 In stock
5 mg ￥5980 In stock
10 mg ￥9580 In stock
25 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A-71623 (A71623) is a cholecystokinin tetrapeptide (30-33) analogue as potent, highly selective CCK-A (CCK1) cholecystokinin receptor agonist with binding IC50 of 3.7 nM, >1000-fold selective over CCK-B receptor.
A-71623 exhibits IC50 values for A-71623 and A-70874 were 3.7 and 4.9 nM in guinea pig pancreas (CCK-A) and 4500 and 710 nM in cerebral cortex (CCK-B), respectively, in radioligand binding assays.
In daily injection studies, the anorectic activity of CCK-8 diminished rapidly, whereas the suppressant effects of A71623 on food intakes and body weight gains persisted throughout the 11-day treatment period.
A71623 reduced the spontaneous locomotor activity of rats at doses above those required to suppress intakes.

物理化学性质&存储条件

分子量 840.98
分子式 C44H56N8O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide

参考文献

1. Lin CW, et al. Mol Pharmacol. 1991 Mar;39(3):346-51.

2. Asin KE, et al. Am J Physiol. 1992 Jul;263(1 Pt 2):R125-35.

3. Asin KE, et al. Pharmacol Biochem Behav. 1992 Aug;42(4):699-704.

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