A66 |CAS:1166227-08-2 Probechem Biochemicals

Chemical Structure : A66

CAS No.: 1166227-08-2

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A66 (p110α inhibitor A66; A-66)

货号: PC-43441Not For Human Use, Lab Use Only.

A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively.

规格	价格	库存
5 mg	￥780	In stock
25 mg	￥1680	In stock
100 mg	￥3580	In stock
500 mg		Get quote

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生物&药学活性

A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively.
A66 displays little to no activity against p110β/γ/δ (IC50>3,000 nM), as well as class-III PI3Ks, mTOR, DNA-PK, and PI4Kα/β.
A66 induces reduction in focus formation CEF by the highly transforming iSH2 mutants KS459delN, DKRMNS560del, and K379E, blocks PI3K signalling and tumour growth in certain cell types.

物理化学性质&存储条件

分子量	393.53
分子式	C17H23N5O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)-

参考文献

1. Jamieson S, et al. Biochem J. 2011 Aug 15;438(1):53-62.

2. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52.

3. Weigelt B, et al. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.

A66 (p110α inhibitor A66; A-66)

生物&药学活性

物理化学性质&存储条件

参考文献

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A66 (p110α inhibitor A66; A-66)

生物&药学活性

物理化学性质&存储条件

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