A438079 hydrochloride

Chemical Structure : A438079 hydrochloride

CAS No.: 899431-18-6

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货号: PC-21904Not For Human Use, Lab Use Only.

A438079 hydrochloride is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3980	In stock
200 mg		Get quote

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生物&药学活性

A438079 hydrochloride is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.
A438079 hows little to no activity at other P2 receptors (IC50 > 10 μM).
A438079 inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.
A438079 possesses antinociceptive activity in models of neuropathic pain in vivo.

物理化学性质&存储条件

分子量	342.61
分子式	C13H10Cl3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine hydrochloride

参考文献

1. Tsukimoto M, et al. Biochem Biophys Res Commun. 2009 Jul 10;384(4):512-8.

2. Nelson DW, et al. J Med Chem. 2006 Jun 15;49(12):3659-66. doi: 10.1021/jm051202e.