Odevixibat (A4250) | ASBT inhibitor | Probechem Biochemicals

Chemical Structure : A4250

CAS No.: 501692-44-0

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A4250 (A-4250, Odevixibat, AZD 8294)

货号: PC-63453Not For Human Use, Lab Use Only.

A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH..

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

A4250 (AZD 8294, Odevixibat) is a selective small molecule inhibitor of apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2).
A4250 (AZD 8294, Odevixibat) showed significant improvement of bile acid-associated hepatobiliary injury in MDR2 (ABCB4) knock-out mice, an established animal model of cholestatic liver disease

物理化学性质&存储条件

分子量	740.931
分子式	C37H48N4O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 2-[[(2R)-[[[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino](4-hydroxyphenyl)acetyl]amino]-, (2S)- (9CI)

参考文献

1. Graffner H, et al. Aliment Pharmacol Ther. 2016 Jan;43(2):303-10.

2. Baghdasaryan A, et al. J Hepatol. 2016 Mar;64(3):674-81.

3. Al-Dury S, et al. Sci Rep. 2018 Apr 27;8(1):6658.

A4250 (A-4250, Odevixibat, AZD 8294)

生物&药学活性

物理化学性质&存储条件

参考文献

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A4250 (A-4250, Odevixibat, AZD 8294)

生物&药学活性

物理化学性质&存储条件

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