A293 (AVE1231)

Chemical Structure : A293

CAS No.: 767334-89-4

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货号: PC-72462Not For Human Use, Lab Use Only.

A293 (AVE1231) is a potent and antiarrhythmic compound and selective inhibitor of two-pore-domain potassium channel TASK-1 (KCNK3, hK2P3.1).

规格	价格	库存
2 mg	￥2280	In stock
5 mg	￥3780	In stock
10 mg	￥5880	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

A293 (AVE1231) is a potent and antiarrhythmic compound and selective inhibitor of two-pore-domain potassium channel TASK-1 (KCNK3, hK2P3.1).
A293 (AVE1231) is an inhibitor of hKv1.5 currents with predominant action on channels in their open state.
A293 (1 uM) prominently depolarized arterial smooth muscle and increased basal tone level and contractile responses to methoxamine of arteries from young rats but had almost no effect in adult rats.
Pharmacological inhibition of atrial TASK-1 currents via A293 (AVE1231) exerts antiarrhythmic effects in vivo as well as in silico, resulting in acute cardioversion of paroxysmal trial fibrillation (AF).

物理化学性质&存储条件

分子量	405.51
分子式	C20H27N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(Butylsulfonamido)-N-(1-(6-methoxypyridin-3-yl)propyl)benzamide

参考文献

1. Wiedmann F, et al. Cell Physiol Biochem. 2019;52(5):1223-1235.

2. Shvetsova AA, et al. Br J Pharmacol. 2020 Nov;177(22):5148-5162.

3. Wirth KJ, et al. J Cardiovasc Pharmacol. 2007 Apr;49(4):197-206.

A293 (AVE1231)

生物&药学活性

物理化学性质&存储条件

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A293 (AVE1231)

生物&药学活性

物理化学性质&存储条件

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