A1899 | TASK-1 inhibitor | Probechem Biochemicals

Chemical Structure : A1899

加入收藏

A1899 (A-1899)

货号: PC-20697Not For Human Use, Lab Use Only.

A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM.
A1899 has IC50 of 7 nM for TASK-1 channels expressed in CHO cells, 10-fold selectivity over TASK-3 channel.
A1899 also displays high selectivity over different potassium channels in Xenopus oocytes.
A1899 interacts with the M2 and M4 transmembrane segments of TASK-1 channels.
A1899 inhibits TASK-1 channels expressed in human and rodent alpha-cells.

物理化学性质&存储条件

分子量	500.55
分子式	C30H26F2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC=CC=C1C2=CC=CC=C2CNC(CC3=CC=C(OC)C=C3)=O)NCC4=CC=C(F)C=C4F

参考文献

1. Streit AK, et al. J Biol Chem. 2011;286:13977.

2. Schiekel J, et al. Cardiovasc Res. 2013 Jan 1;97(1):97-105.

A1899 (A-1899)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

A1899 (A-1899)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.